ACTIVEDORMANCY
Molecular mechanisms through which oocytes evade ageing
Principal Investigator/s
Field / Programme
Quantitative Cell Biology
Quantitative Cell Biology
Summary
Female germ cells, oocytes, can survive for long periods while retaining the ability to create a new organism. The molecular mechanisms that allow oocytes to evade cellular ageing are poorly understood. The ERC-funded ACTIVEDORMANCY project aims to uncover the mechanisms behind the maintenance of cellular fitness and how these mechanisms are affected by ageing, employing imaging and state-of-the-art omics technologies. Oocyte dormancy involves at least two recently discovered unique mechanisms: the suppression of mitochondrial complex I and the constitutive activation of mitochondrial unfolded protein response. The current project will study the metabolic adaptations of cell survival without mitochondrial complex I, the long-lived oocyte proteins and their regulation, and the quality control mechanisms in dormant oocytes.
Female germ cells, oocytes, can survive for long periods while retaining the ability to create a new organism. The molecular mechanisms that allow oocytes to evade cellular ageing are poorly understood. The ERC-funded ACTIVEDORMANCY project aims to uncover the mechanisms behind the maintenance of cellular fitness and how these mechanisms are affected by ageing, employing imaging and state-of-the-art omics technologies. Oocyte dormancy involves at least two recently discovered unique mechanisms: the suppression of mitochondrial complex I and the constitutive activation of mitochondrial unfolded protein response. The current project will study the metabolic adaptations of cell survival without mitochondrial complex I, the long-lived oocyte proteins and their regulation, and the quality control mechanisms in dormant oocytes.
Start: 01/01/2024 End: 31/12/2028
Total Budget: 415.437,50
CRG Budget: 415.437,50
Funded by:
