EpiSperm
Dissecting the role of sperm transcriptome dynamics in intergenerational inheritance through native RNA nanopore sequencing
Principal Investigator/s
Field / Programme
Genome Biology
Genome Biology
Summary
Emerging evidence underscores the importance of environmental factors such as stress, diet and toxins on the epigenetics of mammalian sperm. RNA is considered to carry such epigenetic information across generations and regulate the metabolic health of offspring. Funded by the European Research Council, the EpiSperm project aims to delineate the RNA modifications that affect RNA transcriptomic and epigenetic dynamics in sperm using a novel sequencing technology. Researchers will obtain a holistic view on RNA dynamics at the single-cell level. Moreover, they will unveil candidates that can transmit diet-induced paternal phenotypes to the next generation.
Emerging evidence underscores the importance of environmental factors such as stress, diet and toxins on the epigenetics of mammalian sperm. RNA is considered to carry such epigenetic information across generations and regulate the metabolic health of offspring. Funded by the European Research Council, the EpiSperm project aims to delineate the RNA modifications that affect RNA transcriptomic and epigenetic dynamics in sperm using a novel sequencing technology. Researchers will obtain a holistic view on RNA dynamics at the single-cell level. Moreover, they will unveil candidates that can transmit diet-induced paternal phenotypes to the next generation.
Start: 01/10/2022 End: 30/09/2027
Total Budget: 1.499.427,81
CRG Budget: 1.499.427,81
Funded by:
