HYDRA
Charting the epigenomic trajectory of progression towards metastatic colorectal cancer
Principal Investigator/s
Field / Programme
Genome Biology
Genome Biology
Summary
The aims of the HYDRA project are to: i) characterize the active cis-regulators using integrated multi-omics in patient derived organoids (PDOs) from MRD+/- patients, ii) dissect the alterations in 3D genome topology that denote the molecular switch towards micrometastatic carcinoma by exploiting chromosome conformation capture assays, and iii) investigate the role of candidate TFs in PDOs by gene editing, and the MRD-associated signatures in primary tumors by spatial omics at single-cell resolution.
The aims of the HYDRA project are to: i) characterize the active cis-regulators using integrated multi-omics in patient derived organoids (PDOs) from MRD+/- patients, ii) dissect the alterations in 3D genome topology that denote the molecular switch towards micrometastatic carcinoma by exploiting chromosome conformation capture assays, and iii) investigate the role of candidate TFs in PDOs by gene editing, and the MRD-associated signatures in primary tumors by spatial omics at single-cell resolution.
Start: 01/11/2024 End: 31/10/2027
CRG Budget: 267.913,00
Partners
Funded by:
