The mechanisms underlying Down syndrome (DS) memory deficits are still unknown. New technologies enable the visualization and manipulation of the n
Tumour heterogeneity poses a major challenge for identifying novel drug targets in cancer.
Down syndrome (DS) is the most frequent genetic cause of intellectual disability due to trisomy of human chromosome 21.
Acute Myeloid Leukemia (AML) is an aggressive hematologic malignancy characterized by the accumulation of clonal myeloid progenitor cells arrested
Mantle cell lymphoma (MCL) is a B-cell neoplasm with the majority of patients following an aggressive course. Genome-wide maps of genetic aberratio
DYRK1A is human chromosome 21 (HSA21) gene that encodes a protein kinase, whose expression is increased in Down syndrome (DS) individuals. Aberran
Fertilisation is a multi-step process that culminates in the fusion of the egg and sperm. Although fertilisation is highly dynamic, research has mo
Understanding how individual neurons contribute to network functions is fundamental to neuroscience.
While the number of genetic variants associated with disease continues to increase, their function remains largely unknown. Thus, this project aims
Technical advances in RNA-Seq from individual cells make it possible to profile hundreds of thousands of single cells and to build a Human Cell Atl
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